Fmoc-Val-Lys-PAB-Exatecan
Fmoc-Val-Lys-PAB-Exatecan is a derivative of Exatecan (DX-8951) (HY-13631) . Fmoc-Val-Lys-PAB-Exatecan can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. Fmoc-Val-Lys-PAB-Exatecan is often combined with CD70 mAb to form ADC drugs for the study of tumors with high CD70 expression[1].
Product Specifications
CAS Number
[2901788-27-8]
UNSPSC
12352005
Target
ADC Payload
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Smiles
O=C(OCC1C2=CC=CC=C2C3=CC=CC=C31)N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NC(C=C4)=CC=C4COC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O
Molecular Formula
C58H60FN7O10
Molecular Weight
1034.14
References & Citations
[1]Xiao Shang, et al. CD70 antibody drug conjugates and methods of using them for the treatment of cancer and autoimmune disease. WO2024092067.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Curated Selection
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