PROTAC EGFR degrader 16
PROTAC EGFR degrader 16 (Compound 98) a selective EGFR PROTAC degrader with DC50 values of EGFR L858R-T970M), NCI-H3225 (EGFR L858R) and NCI-H1976 + CS (EGFR L858R-T970M-L797S). PROTAC EGFR degrader 16 can be used for the study of EGFR-driven cancerssuch as non-small cell lung cancer (Pink: EGFR ligand ; Blue: CRBN ligand (HY-W1128702) ; Black: Linker; EGFR ligand + Linker (HY-178311) ).
Product Specifications
CAS Number
2654821-07-3
UNSPSC
12352005
Target
EGFR; PROTACs
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC1=NC=CS1)C(C2=C(CCC3)N3C=N2)N(CC4=C5C=C(C6=CC=C(N(C7)CC87CN(C(CC9(O)CCN(C%10=CC=C(N[C@H](CC%11)C(NC%11=O)=O)C=C%10F)CC9)=O)C8)C=C6)C=C4F)C5=O
Molecular Formula
C48H48F2N10O6S
Molecular Weight
931.02
References & Citations
[1]Christopher G, et al. EGFR DEGRADERS TO TREAT CANCER METASTASIS TO THE BRAIN OR CNS CROSS-REFERENCE TO RELATED APPLICATIONS. WO2022251539.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; EGFR/ErbB1/HER1
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