DX-8951 Hydroxy-acid

DX-8951 Hydroxy-acid is a prodrug of phosphoramide. ProAX can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid has shown significant anti-aging and longevity effects in both human fibroblast and nematode models[1].

Product Specifications

CAS Number

[276680-63-8]

UNSPSC

12352005

Target

AMPK; Drug Metabolite; Reactive Oxygen Species (ROS)

Related Pathways

Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

FC1=CC2=NC3=C(CN4C3=CC([C@@](C(O)=O)(O)CC)=C(CO)C4=O)C([C@@H](N)CC5)=C2C5=C1C

Molecular Formula

C24H24FN3O5

Molecular Weight

453.46

References & Citations

[1]Anada T, et al. A Nucleic Acid Prodrug That Activates Mitochondrial Respiration, Promotes Stress Resilience, and Prolongs Lifespan. J Am Chem Soc. 2025 Jun 25;147 (25) :22161-22175.