CAT335

CAT335 is a TREK activator. CAT335 selectively and irreversibly activates TREK-1CG∗. CAT335 can be used in the research of pain sensation, sleep, and intraocular pressure[1].

Product Specifications

CAS Number

[3032789-44-6]

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C1C=CC(N1C2=CC=C(C(NCC3=CC=C(C=C3Cl)Cl)=O)C=C2)=O

Molecular Formula

C18H12Cl2N2O3

Molecular Weight

375.21

References & Citations

[1]Adam R. RENSLO, et al. Covalent, chemogenetic activators for k2p potassium channels and uses thereof. WO2024064923A2. WIPO (PCT) . 2023-09-22. |[2]Deal PE, et al. Development of covalent chemogenetic K2P channel activators. Cell Chem Biol. 2024 Jul 18;31 (7) :1305-1323.e9.