PBX-7016

PBX-7016 is a Camptothecin (HY-16560) derivative. PBX-7016 can selectively inhibit Topoisomerase 1. PBX-7016 can specifically bind and degrade the cancer protein DDX5, thereby down-regulating the expression of anti-apoptotic proteins such as Survivin, Mcl-1, and XIAP, and promoting the apoptosis of cancer cells. PBX-7016 can be used to synthesis of ADCs[1].

Product Specifications

CAS Number

[3003834-34-9]

UNSPSC

12352005

Target

ADC Payload; Bcl-2 Family; IAP; Survivin; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

C[C@@H](O)C(N[C@@H]1C2=C3C(CC1)=C4C(OCO4)=CC3=NC5=C2CN6C5=CC7=C(COC([C@]7(O)CC)=O)C6=O)=O

Molecular Formula

C27H25N3O8

Molecular Weight

519.50

References & Citations

[1]정두영, et al. Antibody-drug conjugate having camptothecin-based drug linked to antibody having low antigen-binding affinity through linker. WO2024049220A1. 2023-08-30