PROTAC SMARCA2/4 degrader-39
PROTAC SMARCA2/4 degrader-39 (Compound 7) is a selective degrader of SMARCA2 (BRM) and SMARCA4 (BRG1) PROTAC. PROTAC SMARCA2/4 degrader-39 is promising for research of oncology, such as non-small cell lung cancer and colorectal cancer[1]. (Pink: BRM/BRG1 ligand 5 (HY-178886) ; Black: Linker Piperazine (HY-B0912) ; Blue: (S) -Deoxy-thalidomide (HY-168055) )
Product Specifications
CAS Number
[3099581-74-2]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC[C@@](N1C2)(CNC3=C1C=C(C4=C(O)C=CC=C4)N=N3)C[C@H]2OC(N=C5)=C(C)C=C5C(N(CC6)CCN6C7=CC(C8=O)=C(C=C7)CN8[C@H](C(N9)=O)CCC9=O)=O
Molecular Formula
C41H43N9O6
Molecular Weight
757.84
References & Citations
[1]Patent citations (16), et al. Brm and brg1 targeting compounds and associated methods of use. WO2025184459A1. 2026-09-01.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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