Morindone

Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer[1][2].

Product Specifications

CAS Number

[478-29-5]

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O

Molecular Formula

C15H10O5

Molecular Weight

270.24

References & Citations

[1]Chee CW, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells. Chem Biol Interact. 2024 Apr 1;392:110928. |[2]Cheok Wui Chee, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells, Chemico-Biological Interactions, Volume 392, 2024, 110928, ISSN 0009-2797.