Morindone
Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer[1][2].
Product Specifications
CAS Number
478-29-5
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O
Molecular Formula
C15H10O5
Molecular Weight
270.24
References & Citations
[1]Chee CW, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells. Chem Biol Interact. 2024 Apr 1;392:110928. |[2]Cheok Wui Chee, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells, Chemico-Biological Interactions, Volume 392, 2024, 110928, ISSN 0009-2797.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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