Antibacterial agent 292

Antibacterial agent 292 is a 3-pyrazolylindole derivative. Antibacterial agent 292 is an anti-bacterial agent. Antibacterial agent 292 shows potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 and 3.49 μg/mL. Antibacterial agent 292 can suppress biofilm formation, bacterial motility, and extracellular polysaccharide production, induce morphological alterations and promote ROS accumulation, ultimately triggers bacterial apoptosis. Antibacterial agent 292 down-regulates the expression of genes associated with the type VI secretion system (T6SS) . Antibacterial agent 292 can be used in rice bacterial blight and citrus canker[1].

Product Specifications

CAS Number

[3065015-86-0]

UNSPSC

12352005

Target

Apoptosis; Bacterial; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

ClC1=CC=C(CN(CC2)CCN2CC(NC3=CC(C4=CNC5=C4C=CC=C5)=NN3)=O)C=C1

Molecular Formula

C24H25ClN6O

Molecular Weight

448.95

References & Citations

[1]Wu G, et al. Design, Synthesis, and Antibacterial Activity Evaluation and Mechanism of 1-H-Indole-3-pyrazolamide Derivatives Containing Piperazine. J Agric Food Chem. 2025 Sep 24;73 (38) :24404-24415.