SHY-867
SHY-867 is a pan RAS inhibitor. SHY-867 effectively prevents the binding of K-Ras proteins and other members of the Ras superfamily of small GTPases with EC50 values of 0.5-3 μM. SHY-867 effectively inhibits the phosphorylation of MEK, ERK1/2, and AKT downstream of K-Ras. SHY-867 inhibits the formation of the Ras-GTP activity complex. SHY-867 can be used to the studies of pancreatic cancer and non-small cell lung cancer[1].
Product Specifications
CAS Number
2446484-96-2
UNSPSC
12352005
Target
Akt; ERK; MEK; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CO[C@H]1CC[C@H](C1)NC2=NC(C3=NC=CN3C)=NC4=C2C(C5=CC=CC=C5)=C(S4)C6=NN(C=C6)C
Molecular Formula
C26H27N7OS
Molecular Weight
485.60
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; ERK1; ERK2; K-Ras; MEK
Frequently Asked Questions
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