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MDOLL-0286

MDOLL-0286 is a selective Poly (ADP-ribose) Glycohydrolase (PARG) (ARH3) inhibitor with an IC50 of 2.3μM. MDOLL-0286 can inhibit ARH3’s poly-ADP-ribose hydrolytic activity on cellular substrates. MDOLL-0286 can inhibit DNA damage response. MDOLL-0286 can be used for the research of cancer [1].

Product Specifications

UNSPSC

12352005

Target

Poly (ADP-ribose) Glycohydrolase (PARG)

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N=C(N/N=C(C2=CC=C(N(C)C)C=C2)\C)NC(C)=C1C

Molecular Formula

C16H21N5O

Molecular Weight

299.37

References & Citations

[1]Parviainen TAO, et al. Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3. ACS Chem Biol. 2025 Sep 15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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