5-C-phenethyl-DNJ
5-C-phenethyl-DNJ is a selective α-glucosidase GAA inhibitor, with its Ki value for rhGAA being 0.81 μM. 5-C-phenethyl-DNJ exhibits extremely high selectivity for GANAB, GBA1, and GBA2. 5-C-phenethyl-DNJ can be used for the study of Pompe disease[1].
Product Specifications
CAS Number
2734265-58-6
UNSPSC
12352005
Target
Glycosidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O[C@H]1CN[C@](CO)([C@H]([C@@H]1O)O)CCC2=CC=CC=C2
Molecular Formula
C14H21NO4
Molecular Weight
267.32
References & Citations
[1]Vieira Da Cruz A, et al. C-Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal α-Glucosidase for the Treatment of Pompe Disease. J Med Chem. 2025 Sep 25;68 (18) :19269-19286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Glucosidase
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