5-C-phenethyl-DNJ (hydrochloride)

5-C-phenethyl-DNJ hydrochloride is an orally active acid α-glucosidase (GAA) activator. 5-C-phenethyl-DNJ hydrochloride can increase GAA activity in various tissues, particularly in the diaphragm. 5-C-phenethyl-DNJ hydrochloride can be used for the research of metabolic disease, such as Pompe disease[1].

Product Specifications

CAS Number

[2763641-30-9]

UNSPSC

12352005

Target

Glycosidase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

OC[C@@]1([C@H]([C@@H]([C@H](CN1)O)O)O)CCC2=CC=CC=C2.Cl

Molecular Formula

C14H22ClNO4

Molecular Weight

303.78

References & Citations

[1]Vieira Da Cruz A, et al. C-Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal α-Glucosidase for the Treatment of Pompe Disease. J Med Chem. 2025 Sep 25;68 (18) :19269-19286.