Chem-0199
Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer[1].
Product Specifications
UNSPSC
12352005
Target
Akt; DNA/RNA Synthesis; PD-1/PD-L1
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CC1(C)N(O)[C@H](C2=CC=CC=C2)[N+]([O-])=C1CC
Molecular Formula
C13H18N2O2
Molecular Weight
234.29
References & Citations
[1]Wang X, et al. AEBP1 drives fibroblast-mediated T cell dysfunction in tumors. Nat Commun. 2025 Sep 1;16 (1) :8171.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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