MTORC1-IN-3

MTORC1-IN-3 is a potent and selective mTORC1 inhibitor with an IC50 of 26.38 μM . mTORC1-IN-3 selectively inhibits the phosphorylation of mTORC1 substrates and does not without affect the phosphorylation of mTORC2 substrate. mTORC1-IN-3 can reduce cellular lipid accumulation and induce autophagy. mTORC1-IN-3 can be used for the researches of cancer, immunology, metabolic and neurological disease, such as diabetes and Alzheimer’s disease[1].

Product Specifications

UNSPSC

12352005

Target

Autophagy; mTOR

Related Pathways

Autophagy; PI3K/Akt/mTOR

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Smiles

CC1(O[C@@H]2[C@H]([C@H](O[C@@H]2O1)CN3C=C(N=N3)COCC4=C(C5=CC(C6=CN=C(N=C6)N)=CC=C5N=C4)NC7=CC=C(C(C(F)(F)F)=C7)F)OCO[C@H]8[C@H](O[C@H]9[C@@H]8OC(C)(O9)C)CN=[N+]=[N-])C

Molecular Formula

C41H43F4N11O9

Molecular Weight

909.84

References & Citations

[1]Palit S, et al. Glycoconjugation of Quinoline as an Effective Strategy for Selective Inhibition of mTORC1. J Med Chem. 2025 Sep 25;68 (18) :19041-19061.