SGC stimulator 1
SGC stimulator 1 is a carbonyl sulfide (COS) /H2S-donor hybrid soluble guanylyl cyclase (sGC) stimulator (EC50 = 496 nM) . sGC stimulator 1 exhibits a well-characterized H2S-releasing property. sGC stimulator 1 reduces fibrosis in TGF-β1-treated cardiac fibroblasts by increasing cGMP and H2S levels. sGC stimulator 1 can exert anti-fibrotic effects by activating sGC and increasing H2S. sGC stimulator 1 can be used for the study of heart failure (HF) [1].
Product Specifications
UNSPSC
12352005
Target
AMPK; Autophagy; Guanylate Cyclase; TGF-β Receptor
Related Pathways
Autophagy; Epigenetics; GPCR/G Protein; PI3K/Akt/mTOR; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(N=C2N1C=C(C=C2OCC3=C(C=CC=C3F)F)C)C)N[C@H](C(SS4)=NC4=O)C
Molecular Formula
C21H18F2N4O3S2
Molecular Weight
476.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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