WEE1-IN-13
WEE1-IN-13 (Compound 10) is a highly selective WEE1 kinase inhibitor (IC50=0.7 nM) . WEE1-IN-13 abrogates the G2/M checkpoint and induces tumor cell apoptosis. WEE1-IN-13 is promising for research of solid tumors (e.g., non-small cell lung cancer, ovarian cancer) [1].
Product Specifications
UNSPSC
12352005
Target
Wee1
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
C[C@H](C1=C(C2=C(N1C)N=C(N=C2)NC3=CN(N=C3)C4CCN(CC4)C)C#N)C5=CC=CS5
Molecular Formula
C23H26N8S
Molecular Weight
446.57
References & Citations
[1]Knight JL, et al. Harnessing free energy calculations for kinome-wide selectivity in drug discovery campaigns with a Wee1 case study. Nat Commun. 2025 Aug 26;16 (1) :7962.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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