TPG-20A

TPG-20A is a SARS-CoV-2 main protease inhibitor with an IC50 of 27.8 nM. TPG-20A also inhibits MERS-CoV main protease. TPG-20A can be used for the research of infection, such as SARS-CoV-2[1].

Product Specifications

UNSPSC

12352005

Target

SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(C(N1)=CC2=C1C=CC=C2OC)N[C@@H](CC(C)C)C(NN(C(C(Cl)Cl)=O)CC3=CC=CNC3=O)=O

Molecular Formula

C24H27Cl2N5O5

Molecular Weight

536.41

References & Citations

[1]Flury P, et al. Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity. J Med Chem. 2025 Sep 25;68 (18) :19339-19376.