PROTAC CB1R Degrader-1
PROTAC CB1R Degrader-1 is a potent and selective CB1R PROTAC degrader that exploits the ubiquitin-proteasome system (UPS) achieving a DC50 of 3.37 μM in MCF-7 cells and showing no impact on CB2R. PROTAC CB1R Degrader-1 reduces CB1R-associated downstream signaling (p-AKT, p-ERK, BCL2, and MCM5), thereby inhibiting breast cancer cell proliferation and inducing apoptosis. PROTAC CB1R Degrader-1 can be used for breast cancer research. (Blue: CRBN ligand ; Black: linker (HY-178198) ; Pink: CB1R ligand (HY-134497) ).
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; Cannabinoid Receptor; ERK; PROTACs
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; PI3K/Akt/mTOR; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC(C=C1)=CC=C1C(N(N=C2C(NCCN3N=NC(CNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=C3)=O)C7=CC=C(C=C7Cl)Cl)=C2C
Molecular Formula
C35H28Cl3N9O5
Molecular Weight
761.01
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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