MGB4
MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin. MGB4 can be used for the research of cancer, such as Prostate cancer[1].
Product Specifications
UNSPSC
12352100
Target
DNA/RNA Synthesis; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1=C(C(C)C)SC(NC(C2=CC(NC(C3=CC(NC(C4=CSC=N4)=O)=CN3C)=O)=CN2C)=O)=N1)NCCCN(C)C.FC(F)(C(O)=O)F
Molecular Formula
C30H36F3N9O6S2
Molecular Weight
739.79
References & Citations
[1]Zenati RA, et al. Untargeted Multiomics of LNCaP Cell Line Treated with a Novel DNA Minor Groove Binder and/or Doxorubicin Using Mass Spectrometry. J Proteome Res. 2025 Oct 3;24 (10) :4911-4924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Frequently Asked Questions
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