MGB4
MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A) . MGB4 can be used for the research of cancer, such as Prostate cancer[1].
Product Specifications
UNSPSC
12352100
Target
DNA/RNA Synthesis; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1=C(C(C)C)SC(NC(C2=CC(NC(C3=CC(NC(C4=CSC=N4)=O)=CN3C)=O)=CN2C)=O)=N1)NCCCN(C)C.FC(F)(C(O)=O)F
Molecular Formula
C30H36F3N9O6S2
Molecular Weight
739.79
References & Citations
[1]Zenati RA, et al. Untargeted Multiomics of LNCaP Cell Line Treated with a Novel DNA Minor Groove Binder and/or Doxorubicin Using Mass Spectrometry. J Proteome Res. 2025 Oct 3;24 (10) :4911-4924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Curated Selection
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