ARUK2010489

ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7. ARUK2010489 also inhibits CDK2, CDK4 and CDK6 activity, with inhibitory rate of 7%, 39% and 26% at 1 μM. ARUK2010489 can be used for the research of neurological disease, such as Alzheimer’s disease (AD) [1].

Product Specifications

UNSPSC

12352005

Target

AMPK; CDK

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC(N1CCN(C2=CC=C(NC3=NC(OCC4CC4)=C5C(NC=C5)=N3)C=C2)CC1)C

Molecular Formula

C23H30N6O

Molecular Weight

406.52

References & Citations

[1]Gregory G. et al. Development of Purine and Pyrrolopyrimidine Scaffolds as Potent, Selective, and Brain Penetrant NUAK1 Inhibitors ACS Medicinal Chemistry Letters Article ASAP