HDAC degrader-2

HDAC degrader-2 is a selective HDAC degrader with a DC50 values of 2.55 μM against HDAC1. HDAC degrader-2 effectively induces the degradation of HDAC1 and HDAC2, but has no significant effect on the degradation of HDAC3, 4, 6 and 8. HDAC degrader-2 exerts potent antiproliferative effects against MM.1S and MCF-7 cells. HDAC degrader-2 induces apoptosis in myeloma cells. HDAC degrader-2 can be used for the study of myeloma[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; HDAC

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NCCCCCCC(NO)=O)C1=CC=C(C2CC(C3=CC=CC(OCC4=CC=CC=C4)=C3)=NN2C(CCl)=O)C=C1

Molecular Formula

C32H35ClN4O5

Molecular Weight

591.10

References & Citations

[1]Zhai S, et al. Targeted histone deacetylase degradation via chemical induced proximity by direct recruitment of the CUL4 complex adaptor protein DDB1. ACS Medicinal Chemistry Letters. 2025 Aug 20.