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SARS-CoV-2 PLpro-IN-2

SARS-CoV-2 PLpro-IN-2 (Compound 12) is a highly selective SARS-CoV-2 papain-like protease (PLpro) inhibitor of (IC50=0.06 μM) . SARS-CoV-2 PLpro-IN-2 inhibits viral replication and immune evasion. SARS-CoV-2 PLpro-IN-2 exhibits antiviral efficacy in HeLa-ACE2 cells (EC50=2.9 μM) . SARS-CoV-2 PLpro-IN-2 is promising for research of COVID-19[1].

Product Specifications

CAS Number

1581755-42-1

UNSPSC

12352005

Target

SARS-CoV; Virus Protease

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

C[C@@H](N1CCC(C(NCC2=CC=C(Cl)C=C2)=O)CC1)C3=CC=CC4=CC=CC=C43

Molecular Formula

C25H27ClN2O

Molecular Weight

406.95

References & Citations

[1]Gawriljuk VO, et al. Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PLpro) Inhibitors. ACS Omega. 2025 Sep 11;10 (37) :42711-42724.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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