SA91-0178
SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP) -induced and ischemia/reperfusion (I/R) -induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases[1].
Product Specifications
CAS Number
2244341-81-7
UNSPSC
12352005
Target
RNA MTase
Related Pathways
Epigenetics
Field of Research
Inflammation/Immunology
Smiles
O=C(O)C1=CC=CC(CNC(C2=CC=C(N(C)C(C34CCN(C5=CC=CC=C5)CC4)=O)C3=C2)=O)=C1
Molecular Formula
C28H27N3O4
Molecular Weight
469.53
References & Citations
[1]Hou C, et al. METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury. Sci Immunol. 2025 Sep 5;10 (111) :eadv4810.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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