SA91-0178

SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP) -induced and ischemia/reperfusion (I/R) -induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases[1].

Product Specifications

CAS Number

[2244341-81-7]

UNSPSC

12352005

Target

RNA MTase

Related Pathways

Epigenetics

Field of Research

Inflammation/Immunology

Smiles

O=C(O)C1=CC=CC(CNC(C2=CC=C(N(C)C(C34CCN(C5=CC=CC=C5)CC4)=O)C3=C2)=O)=C1

Molecular Formula

C28H27N3O4

Molecular Weight

469.53

References & Citations

[1]Hou C, et al. METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury. Sci Immunol. 2025 Sep 5;10 (111) :eadv4810.