SQS-IN-1
SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer[1].
Product Specifications
CAS Number
2306302-57-6
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; Farnesyl Transferase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CN1CCOC(C2=CC=C(C3=CC=C(C=CC=C4)C4=C3)C=C2)(OCCCO[N+]([O-])=O)C1.Br
Molecular Formula
C24H27BrN2O5
Molecular Weight
503.39
References & Citations
[1]Katavati, Theodora, et al. Unraveling the Potential Pathogenic Role of Squalene Synthase (SQS) in Lung Cancer Using Enzyme Inhibitors as Molecular Tools. ACS Medicinal Chemistry Letters (2025) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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