SQS-IN-1

SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer[1].

Product Specifications

CAS Number

[2306302-57-6]

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; Farnesyl Transferase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CN1CCOC(C2=CC=C(C3=CC=C(C=CC=C4)C4=C3)C=C2)(OCCCO[N+]([O-])=O)C1.Br

Molecular Formula

C24H27BrN2O5

Molecular Weight

503.39

References & Citations

[1]Katavati, Theodora, et al. Unraveling the Potential Pathogenic Role of Squalene Synthase (SQS) in Lung Cancer Using Enzyme Inhibitors as Molecular Tools. ACS Medicinal Chemistry Letters (2025) .