Multi-target kinase-IN-7

Multi-target kinase-IN-7 (Compound 1e) is an orally active multi-target kinase inhibitor (IC50 values: CDK2=0.314 μM, EGFR=0.183 μM, HER-2=0.197 μM, VEGFR-2=0.235 μM) . Multi-target kinase-IN-7 is promising for research of solid tumors (e.g., lung, breast, prostate cancer) [1].

Product Specifications

CAS Number

[301820-47-3]

UNSPSC

12352005

Target

CDK; EGFR; VEGFR

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(/C(N1)=C/C2=CC=C3C=CC=CC3=C2O)N(C4=CC=CC=C4)C1=S

Molecular Formula

C20H14N2O2S

Molecular Weight

346.40

References & Citations

[1]Ali EA, et al. Synthesis and computational investigation of novel 2-mercaptoimidazolones as dual antimicrobial and anti-proliferative agents with potential multitargeting kinase inhibitory activity. Sci Rep. 2025 Aug 27;15 (1) :31527.