Multi-target kinase-IN-7
Multi-target kinase-IN-7 (Compound 1e) is an orally active multi-target kinase inhibitor (IC50 values: CDK2=0.314 μM, EGFR=0.183 μM, HER-2=0.197 μM, VEGFR-2=0.235 μM) . Multi-target kinase-IN-7 is promising for research of solid tumors (e.g., lung, breast, prostate cancer) [1].
Product Specifications
CAS Number
301820-47-3
UNSPSC
12352005
Target
CDK; EGFR; VEGFR
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(/C(N1)=C/C2=CC=C3C=CC=CC3=C2O)N(C4=CC=CC=C4)C1=S
Molecular Formula
C20H14N2O2S
Molecular Weight
346.40
References & Citations
[1]Ali EA, et al. Synthesis and computational investigation of novel 2-mercaptoimidazolones as dual antimicrobial and anti-proliferative agents with potential multitargeting kinase inhibitory activity. Sci Rep. 2025 Aug 27;15 (1) :31527.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; ErbB2/HER2; VEGFR2/KDR/Flk-1
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