AP232

AP232 is a selective U2AF1-UHM Inhibitor with an IC50 of 7.96 μM. AP232 exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 can be used for the research of cancer, such as Leukemia[1].

Product Specifications

UNSPSC

12352005

Target

Autophagy; DNA/RNA Synthesis

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer

Smiles

NC1(C)CCN(C(CCC2=CNC3=C2C(OCC)=CC=C3)C)CC1

Molecular Formula

C20H31N3O

Molecular Weight

329.48

References & Citations

[1]Amol D, et al.. Discovery of the U2AF1-UHM Inhibitor That Possesses AntiLeukemia Activity In Vit. ACS Med. Chem. Lett. 2025, 16, 10, 2015-2021.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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