AP232
AP232 is a selective U2AF1-UHM Inhibitor with an IC50 of 7.96 μM. AP232 exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 can be used for the research of cancer, such as Leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; DNA/RNA Synthesis
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer
Smiles
NC1(C)CCN(C(CCC2=CNC3=C2C(OCC)=CC=C3)C)CC1
Molecular Formula
C20H31N3O
Molecular Weight
329.48
References & Citations
[1]Amol D, et al.. Discovery of the U2AF1-UHM Inhibitor That Possesses AntiLeukemia Activity In Vit. ACS Med. Chem. Lett. 2025, 16, 10, 2015-2021.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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