FB231

FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease[1].

Product Specifications

CAS Number

[2166045-37-8]

UNSPSC

12352005

Target

Mitochondrial Metabolism; PINK1/Parkin

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC1=C(C=CC=C1)C(NC2=NN(C(NC(C3=C(C=CC=C3)C)=O)=N2)C4=CC=CC=C4)=O

Molecular Formula

C24H21N5O2

Molecular Weight

411.46

References & Citations

[1]Rosencrans WM, et al. Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress. Sci Adv. 2025 Aug 29;11 (35) :eady0240.