RuOPt
RuOPt is a photoactivatable Ru (II) -Pt (IV) complex with reduced dark toxicity. Under irradiation, RuOPt induces apoptosis, generates ROS, and inhibits tumor spheroid growth, demonstrating comparable phototoxicity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Photosensitizer; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=C1O[Pt]2(OC1=O)(OCCCOC(CCCC3=CC=[N]([Ru+2]456([N]7=CC=CC=C7C8=[N]6C=CC=C8)[N](C=CC=C9)=C9C%10=CC=CC=[N]%105)C(C%11=[N]4C=CC=C%11)=C3)=O)(OC(C%12=CC=CC=C%12)=O)[NH2][C@@H]%13CCCC[C@H]%13[NH2]2.O=C[O-].O=C[O-]
Molecular Formula
C54H56N8O13PtRu
Molecular Weight
1321.22
References & Citations
[1]Lun Y, et al. A Highly Stable Photoactivatable Pt (IV) Prodrug with Lower Dark Cytotoxicity for Photochemotherapy. Inorg Chem. 2025 Sep 22;64 (37) :18950-18959.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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