CGR-50

CGR-50 is a potent RSV fusion glycoprotein (F protein) inhibitor (EC50 = 32.6 nM against RSV A2 in HEp-2 cells) . CGR-50 blocks RSV entry by binding to the F protein and inhibiting membrane fusion. CGR-50 can be used for RSV infection research[1].

Product Specifications

CAS Number

[3098857-57-6]

UNSPSC

12352005

Target

RSV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(N1CCC(C(F)C(N2CCC([C@@H]3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N

Molecular Formula

C27H30Br2ClFN4O2

Molecular Weight

656.81

References & Citations

[1]Zhang L, et al. Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile. J Med Chem. 2025 Sep 25;68 (18) :18949-18987.