MAO-A/B-IN-5

MAO-A/B-IN-5 is an orally active MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM) inhibitor. MAO-A/B-IN-5 reverses Sodium nitroprusside (SNP) (HY-B0564) -induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM) . MAO-A/B-IN-5 shows dose-dependent and time-dependent antidepressant-like efficacy in mice. MAO-A/B-IN-5 can be used for the study of depressive disorder[1].

Product Specifications

UNSPSC

12352005

Target

Monoamine Oxidase

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC1=CC=C(C(C[N+]2=CC=CC=C2C[Se]C3=CC=CC=C3)=O)C=C1.[Br-]

Molecular Formula

C21H20BrNOSe

Molecular Weight

461.25

References & Citations

[1]Paim MP, et al. Antidepressant-like Properties of a Selenium-Containing Pyridinium Salt Explored through In Vitro, In Vivo, and In Silico Approaches. ACS Chem Neurosci. 2025 Oct 1;16 (19) :3713-3727.