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Mc-Lys (PEG12) -Cap-Ala-Ala-PABC-exatecan

Mc-Lys (PEG12) -Cap-Ala-Ala-PABC-exatecan (compound 12) is a Drug-Linker Conjugate for ADC. Mc-Lys (PEG12) -Cap-Ala-Ala-PABC-exatecan contains the ADC linker (Mc-Lys (PEG12) -Cap-Ala-Ala-PABC) (HY-178146) and a DNA topoisomerase I inhibitor Exatecan (HY-13631) . Mc-Lys (PEG12) -Cap-Ala-Ala-PABC-exatecan can be used for the development of ADC targeting HER2-positive breast cancer[1].

Product Specifications

CAS Number

[3067680-81-0]

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@@H](NC(CCCCCNC([C@@H](NC(CCCCCN8C(C=CC8=O)=O)=O)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)C)=O)C)=O)=O)=C4CN3C2=O)C)=O)O

Molecular Formula

C86H123FN10O26

Molecular Weight

1731.95

References & Citations

[1]Auvert E, et al. Development of Optimized Exatecan-Based Immunoconjugates with Potent Antitumor Efficacy in HER2-Positive Breast Cancer.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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