FPR2 agonist 5

FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056) -induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases[1].

Product Specifications

UNSPSC

12352005

Target

Calcium Channel; Formyl Peptide Receptor (FPR) ; Interleukin Related; NO Synthase

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

N#CC1=CC=C(C[C@H](NC2=NN=C(C3=CC=C(F)C=C3)O2)C(N4CCC5=C4C=CC=C5)=O)C=C1

Molecular Formula

C26H20FN5O2

Molecular Weight

453.47

References & Citations

[1]Francavilla F, et al. Design, Synthesis, and Biological Evaluation of Novel Heteroaryl, Squaramide, and Indolcarboxamide Derivatives as Formyl Peptide Receptor 2 Agonists to Target Neuroinflammation. ACS Chem Neurosci. 2025 Sep 3;16 (17) :3292-3311.