AChE/BuChE-IN-7

AChE/BuChE-IN-7 is a dual-action inhibitor with an IC50 valueof 0.15 μM for AChE and 0.7 μM for BuChE, SI of 4.7. AChE/BuChE-IN-7 shows anti-oxidant activity and can mitigate H2O2-induced cytotoxicity. AChE/BuChE-IN-7 has genomic stability and prolonged systemic availability. AChE/BuChE-IN-7 can be used for the research of neurological disease, such as Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(N1N=C(C)C=C1C)O[C@H](CC2=CC[C@@]3([H])[C@]4([H])CC5)CC[C@]2(C)[C@@]3([H])CC[C@]4(C)C5=O

Molecular Formula

C25H34N2O3

Molecular Weight

410.55

References & Citations

[1]Nar K, et al. DHEA-carbamate derivatives as dual cholinesterase inhibitors: Integration of enzymatic and biomolecular interactions in Alzheimer's disease. Bioorg Chem. 2025 Sep;164:108901.