STAT3-IN-47

STAT3-IN-47 is an orally active STAT3 inhibitor. STAT3-IN-47 exhibits broad-spectrum anti-tumor activity against HeLa, HepG2, U87, and LN229 cells. STAT3-IN-47 suppresses STAT3 activation in vitro. STAT3-IN-47 can be used for the study of solid tumors, especially central nervous system (CNS) malignancies and hepatocellular carcinoma[1].

Product Specifications

CAS Number

[2787548-58-5]

UNSPSC

12352005

Target

STAT

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(C1=C2OC(/C=N/N3C=NNC3=S)=C1)C4=C(C2=O)C=CC=C4

Molecular Formula

C15H8N4O3S

Molecular Weight

324.31

References & Citations

[1]Yin K, et al. Discovery of novel 1,2,4-triazole schiff bases hybridized with 1,4-naphthoquinones as potent STAT3 inhibitors. Bioorg Chem. 2025 Aug 30;165:108936.