HMAO-B-IN-12
HMAO-B-IN-12 (Compound 6E) is a highly selective human monoamine oxidase B (hMAO-B) inhibitor (IC50=17.7 nM) . hMAO-B-IN-12 reduces oxidative stress/lipid metabolism-derived products (e.g., H2O2) . hMAO-B-IN-12 is promising for research of atherosclerosis[1].
Product Specifications
CAS Number
3087062-50-5
UNSPSC
12352005
Target
Monoamine Oxidase
Related Pathways
Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C1C(C2=C([N+]([O-])=O)C=C(C3=CC=CC=C3C(F)(F)F)S2)=CSC4=C1C=CC=C4
Molecular Formula
C20H10F3NO3S2
Molecular Weight
433.42
References & Citations
[1]Lin Y, et al. Discovery of C-3 nitrothiophene substituted thiochromone derivatives as potent and selective human monoamine oxidase B (hMAO-B) inhibitors for the treatment of atherosclerosis. Bioorg Chem. 2025 Aug 31;165:108940.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-B
Frequently Asked Questions
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