HMAO-B-IN-12

HMAO-B-IN-12 (Compound 6E) is a highly selective human monoamine oxidase B (hMAO-B) inhibitor (IC50=17.7 nM) . hMAO-B-IN-12 reduces oxidative stress/lipid metabolism-derived products (e.g., H2O2) . hMAO-B-IN-12 is promising for research of atherosclerosis[1].

Product Specifications

CAS Number

[3087062-50-5]

UNSPSC

12352005

Target

Monoamine Oxidase

Related Pathways

Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=C1C(C2=C([N+]([O-])=O)C=C(C3=CC=CC=C3C(F)(F)F)S2)=CSC4=C1C=CC=C4

Molecular Formula

C20H10F3NO3S2

Molecular Weight

433.42

References & Citations

[1]Lin Y, et al. Discovery of C-3 nitrothiophene substituted thiochromone derivatives as potent and selective human monoamine oxidase B (hMAO-B) inhibitors for the treatment of atherosclerosis. Bioorg Chem. 2025 Aug 31;165:108940.