MyD88-IN-3
MyD88-IN-3 is an orally active, selective MyD88 Inhibitor. MyD88-IN-3 specifically targets the TIR domain of MyD88 (KD = 28.5 μM), thereby preventing MyD88 self-polymerization and interaction with TLRs, which suppresses the activation of MAPK and NF-κB pathways. MyD88-IN-3 demonstrates significant anti-inflammatory efficacy and effectively mitigates Acute Lung Injury (ALI) symptoms in CLP (cecal ligation and puncture) and Lipopolysaccharides (HY-D1056) (LPS) -induced ALI models. MyD88-IN-3 can be used for the study of ALI[1].
Product Specifications
UNSPSC
12352005
Target
JNK; MyD88; NF-κB; p38 MAPK; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=S(C1=CC=C(N2CCN(CC3=CC=C(C#N)C=C3)CC2)C([N+]([O-])=O)=C1)(NC4=CC=C(OC)N=C4)=O
Molecular Formula
C24H24N6O5S
Molecular Weight
508.55
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-178136/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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