Pim-1 kinase-IN-14
Pim-1 kinase-IN-14 is a PIM-1 kinase inhibitor with an IC50 value of 94 nM. Pim-1 kinase-IN-14 shows broad-spectrum and high-efficiency anticancer activity against multiple human cancer cell lines, including liver cancer (HepG-2), colon cancer (Caco-2), myeloid leukemia (NFS-60), and prostate cancer (PC-3) cells. Pim-1 kinase-IN-14exerts its anticancer effects by inducing apoptosis and activating caspase 3/7. Pim-1 kinase-IN-14 can be used for the study of cancers associated with PIM-1 kinase overexpression[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; Pim
Related Pathways
Apoptosis; JAK/STAT Signaling
Field of Research
Cancer
Smiles
N#CC1=C(C2=CC3=CC(Cl)=CC=C3N=C2N4CCOCC4)C=C(C5=CC=CC(O)=C5)N=C1OCC6=CN(C7=CC=C([N+]([O-])=O)C=C7)N=N6
Molecular Formula
C34H25ClN8O5
Molecular Weight
661.07
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1
Frequently Asked Questions
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