Pim-1 kinase-IN-14

Pim-1 kinase-IN-14 is a PIM-1 kinase inhibitor with an IC50 value of 94 nM. Pim-1 kinase-IN-14 shows broad-spectrum and high-efficiency anticancer activity against multiple human cancer cell lines, including liver cancer (HepG-2), colon cancer (Caco-2), myeloid leukemia (NFS-60), and prostate cancer (PC-3) cells. Pim-1 kinase-IN-14exerts its anticancer effects by inducing apoptosis and activating caspase 3/7. Pim-1 kinase-IN-14 can be used for the study of cancers associated with PIM-1 kinase overexpression[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Caspase; Pim

Related Pathways

Apoptosis; JAK/STAT Signaling

Field of Research

Cancer

Smiles

N#CC1=C(C2=CC3=CC(Cl)=CC=C3N=C2N4CCOCC4)C=C(C5=CC=CC(O)=C5)N=C1OCC6=CN(C7=CC=C([N+]([O-])=O)C=C7)N=N6

Molecular Formula

C34H25ClN8O5

Molecular Weight

661.07

References & Citations

[1]Abdelaziz ME, et al. Discovery of new pyridine-O-propargyl/1,2,3-triazole hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities. Bioorg Chem. 2025 Jul 15;162:108564.