Huib32
Huib32 is a potent small-molecule inhibitor of USP32 (IC50 = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion. Huib32 can be used for breast, ovarian, and lung cancer and Alzheimer's and Parkinson’s diseases research[1].
Product Specifications
UNSPSC
12352005
Target
Deubiquitinase
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Purity
98.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NOC(C)=C1S(N2CCC(C(N[C@@H]3CCN(C#N)C3)=O)CC2)(=O)=O
Molecular Formula
C16H23N5O4S
Molecular Weight
381.45
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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