THNAN69

THNAN69 is a potent chemical probe degrader targeting LIMK2, with a DC50 value of 1 nM. THNAN69 can be used for the study of diseases driven by LIMK2 overexpression or dysregulation, such as cancers and ocular diseases[1].

Product Specifications

UNSPSC

12352005

Target

LIM Kinase (LIMK)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CC1=C(N2CCC(NC2=O)=O)C=CC=C1OCC3=CN(N=N3)CCCCC(NC4=NC=C(S4)C5=CC(C(F)F)=NN5C6=C(Cl)C=CC=C6Cl)=O

Molecular Formula

C32H29Cl2F2N9O4S

Molecular Weight

744.60

References & Citations

[1]Kamal Rayees Abdul Azeez, et al. Discovery and development of a potent LIMK2 isoform-specific degrader. SSRN Electronic Journal. 2024, Preprint (SSRN: 5412751)