Lck-IN-4
Lck-IN-4 (Compound A-1) is a protein tyrosine kinase Lck inhibitor with an IC50 of 2 nM. Lck-IN-4 significantly inhibits YAP tyrosine phosphorylation and activity and induces apoptosis in cholangiocarcinoma CCA cells. Lck-IN-4 is cytotoxic in CCA tumor-derived organoids with elevated YAP activity Lck-IN-4 can be used for cancers like cholangiocarcinoma (CCA) research[1].
Product Specifications
CAS Number
[1326278-38-9]
UNSPSC
12352005
Target
Apoptosis; Src
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=NC=CN2C([C@H]3CC[C@H](N4CCN(CC4)C)CC3)=NC(C5=CC(OC)=C(C=C5)NC(C6=CC7=C(OC)C=CC=C7N6C)=O)=C12
Molecular Formula
C36H43N7O3
Molecular Weight
621.77
References & Citations
[1]Buijsman R C, et al. Treatment of subjects suffering from having cholangiocarcinoma. WO2023052406A1. 2023-04-06.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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