HER4/HER2-IN-1

HER4/HER2-IN-1 (Compound 4b) is a HER4/HER2 inhibitor. HER4/HER2-IN-1 inhibits the proliferation of HER2-positive cells. HER4/HER2-IN-1 reduces the total expression level of HER2 in A431 cells, while the phosphorylated HER2 (p-HER2) does not decrease. HER4/HER2-IN-1 lowers the level of cell cycle protein D1 (cyclin D1) and stimulates the cleavage of PARP. HER4/HER2-IN-1 can be used for the study of cancer, such as breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

CDK; EGFR; PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C1C(C2=CC=C(OC)C=C2)=COC3=C1C(CC(C4=C(C)C=C(C)C=C4C)C3)=O

Molecular Formula

C25H24O4

Molecular Weight

388.46

References & Citations

[1]Rubinov DB, et al. A facile method for the preparation of 7,8-dihydro-4H-chromene-4,5 (6H) -diones as non-aromatic cycle A analogs of isoflavones and their evaluation as antiproliferative agents. Bioorg Chem. 2025 Oct;165:108960.