PROTAC PDIA1 degrader 1
PROTAC PDIA1 degrader 1 (Compound H4) is a PDIA1 PROTAC degrader with a DC50 of 29.71 μM. PROTAC PDIA1 degrader 1 has potent anticancer activity and significantly inhibits cancer cell proliferation[1]. Pink: PDIA1 ligand (HY-100433) ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker (HY-W015088)
Product Specifications
CAS Number
[3024292-21-2]
UNSPSC
12352005
Target
PDI; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
COC1=C(N(C(C#C)=O)C(C(NCC(NCCOCCOCCOCCNC2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)=O)=O)C5=CC=CS5)C=CC(OC)=C1
Molecular Formula
C40H44N6O12S
Molecular Weight
832.88
References & Citations
[1]Zhang B, et al. Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation. Bioorg Chem. 2024 Sep;150:107585.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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