HER2-IN-23

HER2-IN-23 is a selective HER2 inhibitor. HER2-IN-23 reduces in total HER2 expression rather than in phosphorylated HER2 (p-HER2) . HER2-IN-23 reduces cyclin D1 level and stimulates PARP cleavage. HER2-IN-23 can be used for the study of HER2-positive breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

EGFR; PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C1C(C2=CC=C(OCC3=CC=CC(F)=C3)C(Cl)=C2)=COC4=C1C(CCC4)=O

Molecular Formula

C22H16ClFO4

Molecular Weight

398.81

References & Citations

[1]Rubinov DB, et al. A facile method for the preparation of 7,8-dihydro-4H-chromene-4,5 (6H) -diones as non-aromatic cycle A analogs of isoflavones and their evaluation as antiproliferative agents. Bioorg Chem. 2025 Oct;165:108960.