MB-Buf
MB-Buf is a conjugation of methylene blue (HY-14536) and bufalin (HY-N0877) . MB-Buf can targeting degrade GPX4 upon light activation. MB-Buf can induce cell apoptosis, ferroptosis, and ROS production. MB-Buf can be used for the research of cancer, such as breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](OC(CC/N=C3C=C4SC5=CC(N(CC)CC)=CC=C5N=C4C6=CC=CC=C/36)=O)C1)C)([H])[C@]2([H])CC7)(CC[C@@H]8C(C=C9)=COC9=O)[C@]78C
Molecular Formula
C47H55N3O5S
Molecular Weight
774.02
References & Citations
[1]Mo X, et al. Design of photoactivatable methylene blue-bufalin conjugate for GPX4-targeted degradation to induce ferroptosis-like death in breast cancer therapy. Bioorg Chem. 2025 Aug;163:108629.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
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