D1R antagonist 2
D1R antagonist 2 (Compound 13a) is a BBB-penetrable D1R antagonist with IC50s of 35.6 and 70 nM for cAMP-based D1R and β-arrestin-based D1R, respectively. D1R antagonist 2 effectively antagonizes D1R-mediated cAMP and β-arrestin recruitment. D1R antagonist 2 can be used for neurodegenerative and neuropsychiatric diseases such as schizophrenia, Parkinson’s disease and Alzheimer’s disease research[1].
Product Specifications
UNSPSC
12352005
Target
Arrestin; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC(F)COC1=C(O)C=C([C@H](CC2=C(Br)C=C(O)C(OCC)=C2C3)N3CC4)C4=C1
Molecular Formula
C21H22BrF2NO4
Molecular Weight
470.30
References & Citations
[1]Namballa HK, et al. Fluoroalkoxylated C-3 and C-9 (S) -12-bromostepholidine analogues with D1R antagonist activity. Bioorg Chem. 2023 Dec;141:106862.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
More Discoveries
Explore Other Products
Browse additional items from our catalog
035309-ML490 100 µL
F2R, NT (F2R, CF2R, PAR1, TR, Proteinase-activated receptor 1, Coagulation factor II receptor, Thrombin receptor) (MaxLight 490) discontinued
Sign In for Pricing
View Details